[PDF] In-silico prediction and validation of Carica papaya protein domains interaction with the Papaya leaf curl virus and associated betasatellite encoded protein | Semantic Scholar (2024)

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@article{Srivastava2024InsilicoPA, title={In-silico prediction and validation of Carica papaya protein domains interaction with the Papaya leaf curl virus and associated betasatellite encoded protein}, author={Aarshi Srivastava and Vineeta Pandey and Avinash Marwal and Akhtar Ali and R. K. Gaur}, journal={Discover Applied Sciences}, year={2024}, url={https://api.semanticscholar.org/CorpusID:270014048}}
  • Aarshi Srivastava, Vineeta Pandey, R. K. Gaur
  • Published in Discover Applied Sciences 22 May 2024
  • Biology, Environmental Science
  • Discover Applied Sciences

This study attempted to understand the sequence–structure relationship and mode of the virus–host binding complex, which was verified and validated with integrative in silico approaches and provided novel insights into the papaya protein–begomovirus protein binding mechanism.

50 References

In silico Prediction and Validations of Domains Involved in Gossypium hirsutum SnRK1 Protein Interaction With Cotton Leaf Curl Multan Betasatellite Encoded βC1

This is the first comprehensive investigation that combined in silico interaction prediction followed by experimental validation of interaction between CLCuMB-βC1 and a host protein, and demonstrated that data from computational biology could provide binding site information between C LCuD-associated viruses/satellites and new hosts that lack known binding site Information for protein–protein interaction studies.

  • 13
  • PDF
Structural insights into the RNA interaction with Yam bean Mosaic virus (coat protein) from Pachyrhizus erosus using bioinformatics approach
    Varsha AcharyaR. Arutselvan M. Nedunchezhiyan

    Biology, Environmental Science

    PloS one

  • 2022

The strongly conserved residues Ser, Arg, and Asp within the RNA binding pocket of YBMV CP indicate the presence of a highly conserved RNA binding site in CPs from different families.

βC1, pathogenicity determinant encoded by Cotton leaf curl Multan betasatellite, interacts with calmodulin-like protein 11 (Gh-CML11) in Gossypium hirsutum
    Hira KamalF. Minhas I. Amin

    Biology, Environmental Science

    PloS one

  • 2019

This is the first comprehensive study on the interaction between CLCuMB-βC1 and Gh-CML11 proteins which provided insights into the understating of the role of βC1 in cotton leaf curl disease.

Identification of Novel Begomoviruses Associated with Leaf Curl Disease of Papaya (Carica papaya L.) in India
    Premchand UdavathaR. Mesta K. S. Shankarappa

    Biology, Agricultural and Food Sciences

    Agronomy

  • 2022

The putative recombination analysis of all 13 papaya isolates showed that a major part of the viral genome was likely descended from the begomoviruses reported previously, and the name Papaya leaf curl Bagalkote virus is proposed.

  • 3
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Manipulation of the Plant Host by the Geminivirus AC2/C2 Protein, a Central Player in the Infection Cycle
    J. GuerreroElizabeth RegedanzLiu LuJianhua RuanD. BisaroG. Sunter

    Biology, Environmental Science

    Frontiers in Plant Science

  • 2020

The role of AC2/C2 in the viral life-cycle is to prevent the host from mounting an efficient defense response to geminivirus infection and to ensure maximal amplification and encapsidation of the viral genome.

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An Insight into Emerging Begomoviruses and their Satellite Complex causing Papaya Leaf Curl Disease
    Aarshi SrivastavaV. PandeyA. Al‐SadiM. ShahidR. K. Gaur

    Biology, Environmental Science

    Current genomics

  • 2023

Current information on the biological functions of papaya-infecting Begomoviruses and their encoded proteins in transmission through vectors and modulating host-mediated responses may improve the understanding of how to challenge these significant plant viruses by revealing new information on the development of antiviral approaches against Begomoviruses associated with PaLCD.

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Papaya Leaf Curl Virus (PaLCuV) Infection on Papaya (Carica papaya L.) Plants Alters Anatomical and Physiological Properties and Reduces Bioactive Components
    S. SoniM. Mishra P. Shirke

    Environmental Science, Biology

    Plants

  • 2022

The research indicates that the PaLCuV-infected leaves not only had anatomical and physiological losses, but that pharmacological potential was also significantly decreased.

Stability of Begomoviral pathogenicity determinant βC1 is modulated by mutually antagonistic SUMOylation and SIM interactions
    A. NairA. Nair P. Shivaprasad

    Biology, Environmental Science

    BMC Biology

  • 2020

The results indicate the presence of a novel mechanism mediating a fine balance between defence and counter-defence in which a SIM site is competitively sought for degradation and, as a counter-Defence, βC1 undergoes SUMOylation to escape from its degradation.

  • 9
  • PDF
betaC1, the pathogenicity factor of TYLCCNV, interacts with AS1 to alter leaf development and suppress selective jasmonic acid responses.
    Jun-Yi YangM. IwasakiC. MachidaY. MachidaXue-ping ZhouN. Chua

    Biology, Environmental Science

  • 2008

It is shown that transgenic Arabidopsis expressing the pathogenesis protein betaC1 of Tomato yellow leaf curl China virus can phenocopy to a large extent disease symptoms of virus-infected tobacco plants in having upward curled leaves, radialized leaves with outgrowth tissues from abaxial surfaces, and sterile flowers.

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Nucleotide sequence and intergeminiviral hom*ologies of the DNA‐A of papaya leaf curl geminivirus from India
    S. SaxenaV. HallanB. SinghP. Sane

    Biology, Environmental Science

    Biochemistry and molecular biology international

  • 1998

Comparison of the coat protein N‐terminal 70 amino acid sequence (and other biological features) of PLCV with other geminiviruses shows that P LCV is a distinct geminvirus from India and is related to WTGs from the old world.

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    [PDF] In-silico prediction and validation of Carica papaya protein domains interaction with the Papaya leaf curl virus and associated betasatellite encoded protein | Semantic Scholar (2024)

    FAQs

    What is the genome of the papaya leaf curl virus? ›

    Genome. This virus typically consists of a bipartite circular single-stranded (ss) DNA molecule (2400–2800 nt in size), and betasatellite (1350-1400 nt in size). Several beta satellites are associated with PaLCuV, and they likely play a role in symptom development.

    What are the medicinal uses of carica papaya? ›

    In traditional medicine, C. papaya has been used as a therapeutic agent due to its wound healing, anti-cancer, hypolipidemic and hypoglycemic properties. Extracts have also been used to treat digestive disorders, arthritis, ringworm, and hypertension [5].

    Which chemical is present in papaya? ›

    papaya contains alkaloids, glycosides, tannins, saponins, flavonoids and glycosides which may be responsible for its therapeutic activity.

    What is the scientific name of papaya? ›

    papaya, (Carica papaya), succulent fruit of a large plant of the family Caricaceae.

    How do you treat papaya leaf curl disease? ›

    There is no chemical treatment for viral infections. However, holding the population of whiteflies in check can reduce the severity of the infection. Soil application at the time of sowing and 4-5 foliar sprays of metasystox at an interval of 10 days can effectively control whitefly populations.

    What is the vector of papaya leaf curl virus? ›

    However, the growth of papaya leaves is adversely impacted by the Geminiviruses, known as papaya leaf curl virus (PaLCuV). The PaLCuV are transmitted to plants through whitefly (Bemisia tabaci) vector.

    What does papaya leaf do to the body? ›

    Leaf juice of papaya is now being known for its potent anticancer [19], antioxidative [4, 5], anti-inflammatory [7], antimicrobial [20], and antisickling properties [21] along with nephron protective [22], hepatoprotective [23], hypoglycaemic, and hypolipidemic effects [24] against toxins in the human system.

    What does papaya do to the body? ›

    Papayas are a sweet fruit and grow in tropical regions. They have many varieties. Papaya has many benefits, including protection against heart disease, reduced inflammation, aid in digestion, and boosting your immune system. There are also benefits to eating papaya seeds.

    What are the side effects of Carica papaya leaf extract? ›

    Side effects associated with Carica papaya leaf extract can range from common and mild, including gastrointestinal discomfort, such as stomach upset or diarrhea, and mild skin irritation, to rare but serious reactions like severe allergies in individuals with known sensitivities to papaya or latex.

    What enzyme is in papaya leaf? ›

    Papaya plant (Carica papaya) produces a specific proteolytic enzyme called papain. This botanically derived exogenous enzyme has numerous health benefits, especially as a protein-dissolving substance (Isa, 2010).

    What not to eat with papaya? ›

    Consuming citrus fruits like orange, grapefruit, or lemon with papaya can result in a sour taste and cause digestive problems. Papaya and citrus fruits contain high levels of vitamin C and may lead to acid reflux, heartburn, and stomach irritation.

    What is the most beneficial compound of papaya? ›

    The papaya fruit is a good source of ascorbic acid (vitamin C) and carotenoids (provitamin A), two important nutrients for people in the subtropical and tropical regions.

    What is the difference between Carica papaya and papaya? ›

    The papaya (/pəˈpaɪə/, US: /pəˈpɑːjə/), papaw, (/pəˈpɔː/) or pawpaw (/ˈpɔːpɔː/) is the plant species Carica papaya, one of the 21 accepted species in the genus Carica of the family Caricaceae, and also the name of its fruit.

    What is the scientific name of leaf curl of papaya? ›

    Scientific Name. Codiaeum leaf curl betasatellite [TAX:2172094] Lineage. Viruses; Tolecusatellitidae; Betasatellite.

    What are the phytochemical analysis of papaya leaves? ›

    Qualitative analysis of papaya leaf extract showed a positive reaction for alkaloids, flavonoids, saponins, phenols, steroids, and tannins. Seurapoh leaf extract showed a positive reaction to Mayer, Wagner, and Dragendorff. Positive results on tannins, steroids, flavonoids, terpenoids, phenols, and saponins.

    What is the genome of TYLCV? ›

    Tomato yellow leaf curl virus (TYLCV) is a monopartite DNA virus with a genome size of ~ 2,800 base pairs. The virus belongs to the genus Begomovirus within the family Geminiviridae. Extant TYLCV strains are differentiated based on an established threshold of 94% genome-wide pairwise nucleotide identity.

    What is the genome of papaya mosaic virus? ›

    The RNA genome of papaya mosaic virus is 6656 nucleotides long [excluding the poly(A) tail] with six open reading frames (ORFs) more than 200 nucleotides long.

    What genome is papaya meleira virus? ›

    PMeV is an isometric virus particle with a double-stranded RNA (dsRNA) genome of approximately 12 Kb. Unusual for a plant virus, PMeV particles are localized on and linked to the polymers present in the latex.

    Is papaya ringspot virus DNA or RNA? ›

    Taxonomy: Papaya ringspot virus (PRSV) is an aphid‐transmitted plant virus belonging to the genus Potyvirus, family Potyviridae, with a positive sense RNA genome.

    References

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